Zollinger-Ellison syndrome

Zollinger-Ellison syndrome is a dangerous tumor disease, characterized by a triad of symptoms. First – gastric hypersecretion. Second – peptic ulcer, arising out of increased acidity of gastric juice in atypical locations. Healed ulcers reopened and do not amenable to treatment by conventional drugs. Third – gastrinoma is a tumor of the islet cells of the pancreas. Gastrinoma may be located outside the pancreas, often in the duodenal wall. This tumor can be located in other organs such as bone, liver, heart, lymph nodes, ovaries.


  • Gastric ulcers, esophagus, small intestine and duodenum.
  • Sometimes, diarrhea, steatorrhea (fat in the stool).
  • Pain in the upper abdomen.


The cause of the disease – swelling of the pancreas that produces gastrin, which stimulates the formation of gastric acid (hydrochloric acid). Due to the fact that increases the amount of acid in the stomach, ulcers occur in the stomach or intestines.


First of all, this syndrome is treated with drugs inhibiting gastric acid production intensive. In the absence of tumor metastasis removed surgically. After surgery, many patients recover completely. If there are metastases or action of drugs that reduce stomach acid, is ineffective, it is necessary to remove the entire stomach (gastrectomy).

The mechanism of pancreatic tumors is not entirely clear, but it can not be independently treat a tumor.

At long pain in the stomach should consult your doctor. First the doctor must refer patients who have had previous gastric surgery, if they are showing symptoms of the disease.

These symptoms may be caused by other diseases. First of all, it is necessary to establish the exact diagnosis of the disease. To do this, take the analysis of gastric juice, perform gastroscopy, as well as determine the concentration of gastrin in the blood.

Furthermore, additional information provided angiographic images of blood vessels that supply blood to the stomach and pancreas, as well as a variety of tests, which promise the development of gastric juice. Today, for the detection of tumors is widely used computed tomography. Having established the diagnosis of the disease, your doctor may offer the necessary treatment or surgery. Gastric infections treated medicines that slow down the formation of gastric acid.

Course of the disease

The causes of pancreatic tumors are not clear. When the pain is in the upper abdomen (especially if they are preceded by an infectious disease) you should consult a doctor. Early treatment reduces the risk of cancer.

Zollinger-Ellison syndrome can get people of any age, but more often it occurs in people 20 to 60 years. With Zollinger-Ellison syndrome first appear gastric and small bowel that can not be medicated. In addition, these ulcers occur in places that are not characteristic of normal gastric ulcer. More than 80% of patients with the above symptoms to diagnose Zollinger-Ellison syndrome was only after more than a year after the onset of the disease. Tumor of the pancreas, causing the disease may metastasize, so it must be timely removal by surgery.

After the gastric surgery, you should regularly visit the doctor. It must do this even if you feel good and you have no ailments.

How dangerous is this syndrome?

Early diagnosis of the disease and the presence of a single tumor increase the likelihood of recovery of the sick. In the late diagnosis and delayed treatment of the syndrome in 60% of patients show a malignant tumor of the pancreas.