Medical Encyclopedia

Chronic myeloid leukemia

What is chronic myeloid leukemia?

This is a type of leukemia with predominance in the peripheral blood of bone marrow elements. Mielos translated from Greek mean bone marrow. The term "leukemia" brings together many of the hematopoietic system tumors arising from hematopoietic cells, and usually affecting the bone marrow. With respect to all leukemia is a clonal theory of their origin: the development of tumors from one originally mutated cell. Leukemia can be treated as a group of benign and malignant tumors. There is a change from the white blood cells. The number of white blood cells varies widely, most of their number increases. At 1 cubic mm blood of a healthy human body contains 5-8 thousand white blood cells. They absorb the bacteria and dead cells, produce antibodies. In leukemia cells grow faster sick. The human body loses its resistance to infectious diseases, heat transfer is disturbed.

Symptoms of chronic myeloid leukemia

  • Pale skin.
  • Bone pain.
  • Heaviness in the left hypochondrium.
  • Emaciation, intolerance to heat, and night sweats.
  • Bleeding tendency.
  • Enlarged spleen.

Symptoms of chronic myeloid leukemia don't appear immediately. Elevated white blood cell count can be detected in blood in connection with any other disease. Although the organism in 90% of patients and found "Philadelphia chromosome", not all of its carriers become ill with leukemia.

Causes of chronic myeloid leukemia

The cause is not certain, but this disease can be caused by ionizing radiation.

Treatment of chronic myeloid leukemia

Chronic myeloid leukemia

Typically, doctors use in the treatment of cytotoxic (cell poisons that block the growth of all cells). The first drugs inhibit tumor cells. However, it causes side effects such as inflammation of the mucous membrane of the stomach and intestines, hair loss, nausea, etc. It is necessary to carry out radiation therapy, blood transfusions, bone marrow transplantation.

Self-treatment of chronic myeloid leukemia is not possible.

If the cases of infectious disease or recurrent bleeding worry (eg, nasal), you should consult your doctor. Specific symptom of chronic myeloid leukemia - hypersensitivity to touch the sternum, it may be some softening.

Course of the disease

Neoplastic process has two stages - an expanded and terminal. The disease develops slowly, after a while, general weakness, heaviness in the left hypochondrium. Spleen and liver increased, but without pain. The initial manifestation of the disease neuralgia may be caused by compression of the nerve trunks of leukemic infiltrates. The disease is accompanied by paleness of the skin, tachycardia, pleurisy, bronchitis. As the disease progresses anemia, leukocytosis increases. The terminal stage is characterized by a significant worsening of the patient, weight loss, fever, unmotivated, a rapid increase in the spleen. Almost constant excruciating bone pain associated with the growth of tumors. They occur in the skin, lymph nodes, and membranes of the brain matter and all other organs. Absolutely reliable in the presence of myeloid cells so-called "Philadelphia chromosome." Prognosis of the disease is fatal to the patient.

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Basalioma

Lymphogranulomatosis